University of Hertfordshire

From the same journal

By the same authors

Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status

Research output: Contribution to journal › Article › peer-review

Standard

Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status. / Antrobus, M; Brazier, Jon; Callus, P; Herbert, A; Stebbings, G; Day, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Collins, M.; Pitsiladis, Y; Heffernan, S; Williams, A.

In: Clinical Journal of Sport Medicine, 29.03.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Antrobus, M, Brazier, J, Callus, P, Herbert, A, Stebbings, G, Day, S, Kilduff, L, Bennett, M, Erskine, R, Raleigh, S, Collins, M, Pitsiladis, Y, Heffernan, S & Williams, A 2022, 'Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status', Clinical Journal of Sport Medicine. https://doi.org/10.1097/JSM.0000000000001030

APA

Antrobus, M., Brazier, J., Callus, P., Herbert, A., Stebbings, G., Day, S., Kilduff, L., Bennett, M., Erskine, R., Raleigh, S., Collins, M., Pitsiladis, Y., Heffernan, S., & Williams, A. (2022). Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status. Clinical Journal of Sport Medicine. https://doi.org/10.1097/JSM.0000000000001030

Vancouver

Antrobus M, Brazier J, Callus P, Herbert A, Stebbings G, Day S et al. Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status. Clinical Journal of Sport Medicine. 2022 Mar 29. https://doi.org/10.1097/JSM.0000000000001030

Author

Antrobus, M ; Brazier, Jon ; Callus, P ; Herbert, A ; Stebbings, G ; Day, S ; Kilduff, L ; Bennett, M ; Erskine, R ; Raleigh, Stuart ; Collins, M. ; Pitsiladis, Y ; Heffernan, S ; Williams, A. / Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status. In: Clinical Journal of Sport Medicine. 2022.

Bibtex

@article{9e1ef134a4324922944a5a453fd54be7,
title = "Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status",
abstract = "Objective:Concussions are common match injuries in elite rugby and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. The aim of this study was to investigate the association between elite rugby status and eight concussion-associated risk polymorphisms. We hypothesized that concussion-associated risk genotypes and alleles would be underrepresented in elite rugby athletes compared to non-athletes.Design:A case-control genetic association study.Setting:Institutional (university).Participants:Elite Caucasian male rugby athletes (n = 668, mean (standard deviation) height 1.85 (0.07) m, mass 102 (12) kg, age 29 (7) yr) and 1015 non-athlete Caucasian men and women (48% men).Interventions:Genotype was the independent variable, obtained via PCR of genomic DNA using TaqMan probes.Main Outcome Measure:Elite athlete status, with groups compared using χ2 and odds ratio.Results:The COMT rs4680 Met/Met (AA) genotype, Met allele possession and Met allele frequency were lower in rugby athletes (24.8%, 74.6% and 49.7%, respectively) than non-athletes (30.2%, 77.6%, and 54.0%; P < 0.05). The Val/Val (GG) genotype was more common in elite rugby athletes than non-athletes (odds ratio 1.39, 95% confidence interval 1.04-1.86). No other polymorphism was associated with elite athlete status.Conclusions:Elite rugby athlete status is associated with COMT rs4680 genotype that, acting pleiotropically, could affect stress resilience and behavioral traits during competition, concussion risk and/or recovery from concussion. Consequently, assessing COMT rs4680 genotype might aid future individualized management of concussion risk amongst athletes.",
author = "M Antrobus and Jon Brazier and P Callus and A Herbert and G Stebbings and S Day and L Kilduff and M Bennett and R Erskine and Stuart Raleigh and M. Collins and Y Pitsiladis and S Heffernan and A Williams",
note = " {\textcopyright} 2022 Wolters Kluwer Health, Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1097/JSM.0000000000001030",
year = "2022",
month = mar,
day = "29",
doi = "10.1097/JSM.0000000000001030",
language = "English",
journal = "Clinical Journal of Sport Medicine",
issn = "1050-642X",
publisher = "Lippincott Williams and Wilkins",

}

RIS

TY - JOUR

T1 - Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status

AU - Antrobus, M

AU - Brazier, Jon

AU - Callus, P

AU - Herbert, A

AU - Stebbings, G

AU - Day, S

AU - Kilduff, L

AU - Bennett, M

AU - Erskine, R

AU - Raleigh, Stuart

AU - Collins, M.

AU - Pitsiladis, Y

AU - Heffernan, S

AU - Williams, A

N1 - © 2022 Wolters Kluwer Health, Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1097/JSM.0000000000001030

PY - 2022/3/29

Y1 - 2022/3/29

N2 - Objective:Concussions are common match injuries in elite rugby and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. The aim of this study was to investigate the association between elite rugby status and eight concussion-associated risk polymorphisms. We hypothesized that concussion-associated risk genotypes and alleles would be underrepresented in elite rugby athletes compared to non-athletes.Design:A case-control genetic association study.Setting:Institutional (university).Participants:Elite Caucasian male rugby athletes (n = 668, mean (standard deviation) height 1.85 (0.07) m, mass 102 (12) kg, age 29 (7) yr) and 1015 non-athlete Caucasian men and women (48% men).Interventions:Genotype was the independent variable, obtained via PCR of genomic DNA using TaqMan probes.Main Outcome Measure:Elite athlete status, with groups compared using χ2 and odds ratio.Results:The COMT rs4680 Met/Met (AA) genotype, Met allele possession and Met allele frequency were lower in rugby athletes (24.8%, 74.6% and 49.7%, respectively) than non-athletes (30.2%, 77.6%, and 54.0%; P < 0.05). The Val/Val (GG) genotype was more common in elite rugby athletes than non-athletes (odds ratio 1.39, 95% confidence interval 1.04-1.86). No other polymorphism was associated with elite athlete status.Conclusions:Elite rugby athlete status is associated with COMT rs4680 genotype that, acting pleiotropically, could affect stress resilience and behavioral traits during competition, concussion risk and/or recovery from concussion. Consequently, assessing COMT rs4680 genotype might aid future individualized management of concussion risk amongst athletes.

AB - Objective:Concussions are common match injuries in elite rugby and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. The aim of this study was to investigate the association between elite rugby status and eight concussion-associated risk polymorphisms. We hypothesized that concussion-associated risk genotypes and alleles would be underrepresented in elite rugby athletes compared to non-athletes.Design:A case-control genetic association study.Setting:Institutional (university).Participants:Elite Caucasian male rugby athletes (n = 668, mean (standard deviation) height 1.85 (0.07) m, mass 102 (12) kg, age 29 (7) yr) and 1015 non-athlete Caucasian men and women (48% men).Interventions:Genotype was the independent variable, obtained via PCR of genomic DNA using TaqMan probes.Main Outcome Measure:Elite athlete status, with groups compared using χ2 and odds ratio.Results:The COMT rs4680 Met/Met (AA) genotype, Met allele possession and Met allele frequency were lower in rugby athletes (24.8%, 74.6% and 49.7%, respectively) than non-athletes (30.2%, 77.6%, and 54.0%; P < 0.05). The Val/Val (GG) genotype was more common in elite rugby athletes than non-athletes (odds ratio 1.39, 95% confidence interval 1.04-1.86). No other polymorphism was associated with elite athlete status.Conclusions:Elite rugby athlete status is associated with COMT rs4680 genotype that, acting pleiotropically, could affect stress resilience and behavioral traits during competition, concussion risk and/or recovery from concussion. Consequently, assessing COMT rs4680 genotype might aid future individualized management of concussion risk amongst athletes.

U2 - 10.1097/JSM.0000000000001030

DO - 10.1097/JSM.0000000000001030

M3 - Article

JO - Clinical Journal of Sport Medicine

JF - Clinical Journal of Sport Medicine

SN - 1050-642X

ER -