University of Hertfordshire

Defining remission by cut off score on the MADRS: selecting the optimal value

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Defining remission by cut off score on the MADRS : selecting the optimal value. / Hawley, C.; Gale, T.M.; Sivakumaran, T.

In: Journal of Affective Disorders, Vol. 72, No. 2, 2002, p. 177-184.

Research output: Contribution to journalArticle

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Hawley, C. ; Gale, T.M. ; Sivakumaran, T. / Defining remission by cut off score on the MADRS : selecting the optimal value. In: Journal of Affective Disorders. 2002 ; Vol. 72, No. 2. pp. 177-184.

Bibtex

@article{27041057a95548b194d4a27b0cb39a17,
title = "Defining remission by cut off score on the MADRS: selecting the optimal value",
abstract = "Background: Remission from major depression may be conceptualised in terms of a cut-off score on an appropriate rating scale. Candidate values proposed hitherto have not been directly validated. Method: The relationship between The Clinical Global Impression Scale for Severity (CGI-S) and the Montgomery–{\AA}sberg Depression Rating Scale (M{\AA}DRS) was explored in 684 major depressed patients (1114 observations). The value on the M{\AA}DRS which had greatest concordance with remission, as defined by the CGI-S, was computed using two models. Concordance between clinician and patient judgements of global illness were also compared. Results and conclusion: The two models yielded optimal definitions of remission of <9 and <10 on the M{\AA}DRS. Either value offers a workable operationalisation of remission and there is little to choose between them. Clinical relevance: The data confirm that MADRS <10 should provide the clinician with a valid, and reasonably objectifiable, target for remission.",
author = "C. Hawley and T.M. Gale and T. Sivakumaran",
note = "Original article can be found at: http://www.sciencedirect.com/science/journal/01650327 Copyright Elsevier Inc. [Full text of this article is not available in the UHRA]",
year = "2002",
doi = "10.1016/S0165-0327(01)00451-7",
language = "English",
volume = "72",
pages = "177--184",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Defining remission by cut off score on the MADRS

T2 - selecting the optimal value

AU - Hawley, C.

AU - Gale, T.M.

AU - Sivakumaran, T.

N1 - Original article can be found at: http://www.sciencedirect.com/science/journal/01650327 Copyright Elsevier Inc. [Full text of this article is not available in the UHRA]

PY - 2002

Y1 - 2002

N2 - Background: Remission from major depression may be conceptualised in terms of a cut-off score on an appropriate rating scale. Candidate values proposed hitherto have not been directly validated. Method: The relationship between The Clinical Global Impression Scale for Severity (CGI-S) and the Montgomery–Åsberg Depression Rating Scale (MÅDRS) was explored in 684 major depressed patients (1114 observations). The value on the MÅDRS which had greatest concordance with remission, as defined by the CGI-S, was computed using two models. Concordance between clinician and patient judgements of global illness were also compared. Results and conclusion: The two models yielded optimal definitions of remission of <9 and <10 on the MÅDRS. Either value offers a workable operationalisation of remission and there is little to choose between them. Clinical relevance: The data confirm that MADRS <10 should provide the clinician with a valid, and reasonably objectifiable, target for remission.

AB - Background: Remission from major depression may be conceptualised in terms of a cut-off score on an appropriate rating scale. Candidate values proposed hitherto have not been directly validated. Method: The relationship between The Clinical Global Impression Scale for Severity (CGI-S) and the Montgomery–Åsberg Depression Rating Scale (MÅDRS) was explored in 684 major depressed patients (1114 observations). The value on the MÅDRS which had greatest concordance with remission, as defined by the CGI-S, was computed using two models. Concordance between clinician and patient judgements of global illness were also compared. Results and conclusion: The two models yielded optimal definitions of remission of <9 and <10 on the MÅDRS. Either value offers a workable operationalisation of remission and there is little to choose between them. Clinical relevance: The data confirm that MADRS <10 should provide the clinician with a valid, and reasonably objectifiable, target for remission.

U2 - 10.1016/S0165-0327(01)00451-7

DO - 10.1016/S0165-0327(01)00451-7

M3 - Article

VL - 72

SP - 177

EP - 184

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 2

ER -