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Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries. / Rice, P.; Brown, Roger F. R.; Lam, D. G. K. ; Chilcott, Robert; Bennett, N. J. .

In: Burns, Vol. 26, No. 1, 02.2000, p. 34-40.

Research output: Contribution to journalArticle

Harvard

Rice, P, Brown, RFR, Lam, DGK, Chilcott, R & Bennett, NJ 2000, 'Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries', Burns, vol. 26, no. 1, pp. 34-40.

APA

Rice, P., Brown, R. F. R., Lam, D. G. K., Chilcott, R., & Bennett, N. J. (2000). Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries. Burns, 26(1), 34-40.

Vancouver

Author

Rice, P. ; Brown, Roger F. R. ; Lam, D. G. K. ; Chilcott, Robert ; Bennett, N. J. . / Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries. In: Burns. 2000 ; Vol. 26, No. 1. pp. 34-40.

Bibtex

@article{7227a40c611544eda7a88018366db2e2,
title = "Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries",
abstract = "Since its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective treatment for these injuries has been slow due to the lack of suitable animal models upon which to study the toxicology and pathology. However, porcine and human skin are similar in structure and exposures to sulphur mustard vapour have been performed on porcine models to define the development and subsequent resolution of mustard-induced skin injuries. Yucatan miniature (n = 12) and large white (n = 6) pig models were used to assess the usefulness of mechanical dermabrasion in accelerating the naturally slow rate of healing of sulphur mustard vapour-induced injuries to the skin. Burn injuries underwent debridement at 4 days postexposure and the resulting lesions were assessed at various time points up to 8 weeks post-abrasion.Rates of re-epithelialisation were accelerated in the dermabrasion (treated) vs the control (untreated) group by up to a factor of three (ANOVA: p = 0.0196, Yucatan; p = 0.165, large white pig). It was concluded that dermabrasion of sulphur mustard burns is a valuable procedure in the surgical management of these injuries. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.",
keywords = "sulphur mustard, skin burn(s), healing, surgical treatment, dermabrasion, ATHYMIC NUDE-MICE, SULFUR MUSTARD, SKIN, MINIPIG, MODEL, PIG",
author = "P. Rice and Brown, {Roger F. R.} and Lam, {D. G. K.} and Robert Chilcott and Bennett, {N. J.}",
year = "2000",
month = feb,
language = "English",
volume = "26",
pages = "34--40",
journal = "Burns",
issn = "0305-4179",
publisher = "Elsevier Limited",
number = "1",

}

RIS

TY - JOUR

T1 - Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries

AU - Rice, P.

AU - Brown, Roger F. R.

AU - Lam, D. G. K.

AU - Chilcott, Robert

AU - Bennett, N. J.

PY - 2000/2

Y1 - 2000/2

N2 - Since its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective treatment for these injuries has been slow due to the lack of suitable animal models upon which to study the toxicology and pathology. However, porcine and human skin are similar in structure and exposures to sulphur mustard vapour have been performed on porcine models to define the development and subsequent resolution of mustard-induced skin injuries. Yucatan miniature (n = 12) and large white (n = 6) pig models were used to assess the usefulness of mechanical dermabrasion in accelerating the naturally slow rate of healing of sulphur mustard vapour-induced injuries to the skin. Burn injuries underwent debridement at 4 days postexposure and the resulting lesions were assessed at various time points up to 8 weeks post-abrasion.Rates of re-epithelialisation were accelerated in the dermabrasion (treated) vs the control (untreated) group by up to a factor of three (ANOVA: p = 0.0196, Yucatan; p = 0.165, large white pig). It was concluded that dermabrasion of sulphur mustard burns is a valuable procedure in the surgical management of these injuries. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.

AB - Since its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective treatment for these injuries has been slow due to the lack of suitable animal models upon which to study the toxicology and pathology. However, porcine and human skin are similar in structure and exposures to sulphur mustard vapour have been performed on porcine models to define the development and subsequent resolution of mustard-induced skin injuries. Yucatan miniature (n = 12) and large white (n = 6) pig models were used to assess the usefulness of mechanical dermabrasion in accelerating the naturally slow rate of healing of sulphur mustard vapour-induced injuries to the skin. Burn injuries underwent debridement at 4 days postexposure and the resulting lesions were assessed at various time points up to 8 weeks post-abrasion.Rates of re-epithelialisation were accelerated in the dermabrasion (treated) vs the control (untreated) group by up to a factor of three (ANOVA: p = 0.0196, Yucatan; p = 0.165, large white pig). It was concluded that dermabrasion of sulphur mustard burns is a valuable procedure in the surgical management of these injuries. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.

KW - sulphur mustard

KW - skin burn(s)

KW - healing

KW - surgical treatment

KW - dermabrasion

KW - ATHYMIC NUDE-MICE

KW - SULFUR MUSTARD

KW - SKIN

KW - MINIPIG

KW - MODEL

KW - PIG

M3 - Article

VL - 26

SP - 34

EP - 40

JO - Burns

JF - Burns

SN - 0305-4179

IS - 1

ER -