University of Hertfordshire

Drug-related problems in cardiac children

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Drug-related problems in cardiac children. / Sabry, Nirmeen; Farid, Samar; Dawoud, Dalia.

In: Minerva pediatrica, Vol. 68, No. 2, 01.04.2016, p. 89-95.

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Sabry N, Farid S, Dawoud D. Drug-related problems in cardiac children. Minerva pediatrica. 2016 Apr 1;68(2):89-95.

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Sabry, Nirmeen ; Farid, Samar ; Dawoud, Dalia. / Drug-related problems in cardiac children. In: Minerva pediatrica. 2016 ; Vol. 68, No. 2. pp. 89-95.

Bibtex

@article{23d9092dce8f4a7b90c1d646f2a0d9f1,
title = "Drug-related problems in cardiac children",
abstract = "BACKGROUND: A drug-related problem (DRP) may be defined as {"}an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome{"}. Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the Egyptian capital, Cairo.METHODS: A prospective observational cohort study involving review of case notes for children aged 0-18 years, admitted to the medical ward and intensive care unit (ICU), was conducted at a tertiary cardiac care center in Egypt. Data collection took place over a three-month period. Daily reviews of patients' records, medication charts and laboratory data were undertaken by the clinical pharmacists to identify DRPs.RESULTS: A total of 60 patients were included in the study (mean age 4.8 years; 53.33% males). Over a three-month period, a total of 313 DRPs were recorded corresponding to an average of 5.22 problems per patient. The most commonly recorded problems related to drug-drug interaction (45.69%), prescribing unnecessary medication (31.95%), under-dosing (21.09%), inappropriate medication (0.96%) and adverse drug reaction (0.32%). Prophylactic antibiotics represented the only unnecessarily prescribed medications. Of the pharmacist suggested interventions, 65% were accepted by the responsible physician.CONCLUSIONS: DRPs occurred frequently during the study period. Drug-drug interactions, drug choice and drug dosing problems represented the majority of the identified DRPs, necessitating targeted prescriber education interventions in these areas. There is a clear need for clinical pharmacists' involvement on the ward level to identify and rectify these frequently occurring and very costly problems.",
keywords = "Adolescent, Cardiac Care Facilities, Child, Child, Preschool, Cohort Studies, Dose-Response Relationship, Drug, Drug Interactions, Drug-Related Side Effects and Adverse Reactions/epidemiology, Egypt, Female, Heart Diseases/physiopathology, Hospitalization, Humans, Inappropriate Prescribing/statistics & numerical data, Infant, Infant, Newborn, Male, Pharmacists, Practice Patterns, Physicians'/standards, Prospective Studies, Tertiary Care Centers",
author = "Nirmeen Sabry and Samar Farid and Dalia Dawoud",
note = "{\textcopyright} 2016 EDIZIONI MINERVA MEDICA",
year = "2016",
month = apr,
day = "1",
language = "English",
volume = "68",
pages = "89--95",
journal = "Minerva pediatrica",
issn = "0026-4946",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

RIS

TY - JOUR

T1 - Drug-related problems in cardiac children

AU - Sabry, Nirmeen

AU - Farid, Samar

AU - Dawoud, Dalia

N1 - © 2016 EDIZIONI MINERVA MEDICA

PY - 2016/4/1

Y1 - 2016/4/1

N2 - BACKGROUND: A drug-related problem (DRP) may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome". Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the Egyptian capital, Cairo.METHODS: A prospective observational cohort study involving review of case notes for children aged 0-18 years, admitted to the medical ward and intensive care unit (ICU), was conducted at a tertiary cardiac care center in Egypt. Data collection took place over a three-month period. Daily reviews of patients' records, medication charts and laboratory data were undertaken by the clinical pharmacists to identify DRPs.RESULTS: A total of 60 patients were included in the study (mean age 4.8 years; 53.33% males). Over a three-month period, a total of 313 DRPs were recorded corresponding to an average of 5.22 problems per patient. The most commonly recorded problems related to drug-drug interaction (45.69%), prescribing unnecessary medication (31.95%), under-dosing (21.09%), inappropriate medication (0.96%) and adverse drug reaction (0.32%). Prophylactic antibiotics represented the only unnecessarily prescribed medications. Of the pharmacist suggested interventions, 65% were accepted by the responsible physician.CONCLUSIONS: DRPs occurred frequently during the study period. Drug-drug interactions, drug choice and drug dosing problems represented the majority of the identified DRPs, necessitating targeted prescriber education interventions in these areas. There is a clear need for clinical pharmacists' involvement on the ward level to identify and rectify these frequently occurring and very costly problems.

AB - BACKGROUND: A drug-related problem (DRP) may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome". Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the Egyptian capital, Cairo.METHODS: A prospective observational cohort study involving review of case notes for children aged 0-18 years, admitted to the medical ward and intensive care unit (ICU), was conducted at a tertiary cardiac care center in Egypt. Data collection took place over a three-month period. Daily reviews of patients' records, medication charts and laboratory data were undertaken by the clinical pharmacists to identify DRPs.RESULTS: A total of 60 patients were included in the study (mean age 4.8 years; 53.33% males). Over a three-month period, a total of 313 DRPs were recorded corresponding to an average of 5.22 problems per patient. The most commonly recorded problems related to drug-drug interaction (45.69%), prescribing unnecessary medication (31.95%), under-dosing (21.09%), inappropriate medication (0.96%) and adverse drug reaction (0.32%). Prophylactic antibiotics represented the only unnecessarily prescribed medications. Of the pharmacist suggested interventions, 65% were accepted by the responsible physician.CONCLUSIONS: DRPs occurred frequently during the study period. Drug-drug interactions, drug choice and drug dosing problems represented the majority of the identified DRPs, necessitating targeted prescriber education interventions in these areas. There is a clear need for clinical pharmacists' involvement on the ward level to identify and rectify these frequently occurring and very costly problems.

KW - Adolescent

KW - Cardiac Care Facilities

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Dose-Response Relationship, Drug

KW - Drug Interactions

KW - Drug-Related Side Effects and Adverse Reactions/epidemiology

KW - Egypt

KW - Female

KW - Heart Diseases/physiopathology

KW - Hospitalization

KW - Humans

KW - Inappropriate Prescribing/statistics & numerical data

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Pharmacists

KW - Practice Patterns, Physicians'/standards

KW - Prospective Studies

KW - Tertiary Care Centers

M3 - Article

C2 - 25034220

VL - 68

SP - 89

EP - 95

JO - Minerva pediatrica

JF - Minerva pediatrica

SN - 0026-4946

IS - 2

ER -