University of Hertfordshire

Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis

Research output: Contribution to journalArticlepeer-review

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Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis. / Korsunskiy, Ilya; Blyuss, Oleg; Gordukova, Maria; Davydova, Nataliia; Zaikin, Alexey; Zinovieva, Nataliia; Zimin, Sergey; Molchanov, Robert; Salpagarova, Aminat; Filipenko, Maxim; Eremeeva, Alina; Prodeus, Andrey; Korsunskiy, Anatoliy; Hsu, Peter; Munblit, Daniel.

In: Frontiers in Immunology, Vol. 11, 320, 03.03.2020, p. 320.

Research output: Contribution to journalArticlepeer-review

Harvard

Korsunskiy, I, Blyuss, O, Gordukova, M, Davydova, N, Zaikin, A, Zinovieva, N, Zimin, S, Molchanov, R, Salpagarova, A, Filipenko, M, Eremeeva, A, Prodeus, A, Korsunskiy, A, Hsu, P & Munblit, D 2020, 'Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis', Frontiers in Immunology, vol. 11, 320, pp. 320. https://doi.org/10.3389/fimmu.2020.00320

APA

Korsunskiy, I., Blyuss, O., Gordukova, M., Davydova, N., Zaikin, A., Zinovieva, N., Zimin, S., Molchanov, R., Salpagarova, A., Filipenko, M., Eremeeva, A., Prodeus, A., Korsunskiy, A., Hsu, P., & Munblit, D. (2020). Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis. Frontiers in Immunology, 11, 320. [320]. https://doi.org/10.3389/fimmu.2020.00320

Vancouver

Author

Korsunskiy, Ilya ; Blyuss, Oleg ; Gordukova, Maria ; Davydova, Nataliia ; Zaikin, Alexey ; Zinovieva, Nataliia ; Zimin, Sergey ; Molchanov, Robert ; Salpagarova, Aminat ; Filipenko, Maxim ; Eremeeva, Alina ; Prodeus, Andrey ; Korsunskiy, Anatoliy ; Hsu, Peter ; Munblit, Daniel. / Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis. In: Frontiers in Immunology. 2020 ; Vol. 11. pp. 320.

Bibtex

@article{214c8e168e9848c6a5c9155b8a420bef,
title = "Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis",
abstract = "Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific symptoms. This study aimed to assess TREC and KREC diagnostic ability in PID. Data from children assessed by clinical immunologists at Speransky Children's Hospital, Moscow, Russia with suspected immunodeficiencies were analyzed between May 2013 and August 2016. Peripheral blood samples were sent for TREC/KREC, flow cytometry (CD3, CD4, CD8 and CD19), IgA and IgG analysis. A total of 434 children [189 healthy, 97 with group I and II PID (combined T and B cell immunodeficiencies & well-defined syndromes with immunodeficiency) and 148 group III PID (predominantly antibody deficiencies)] were included. Area under the curve (AUC) for TREC in PID groups I and II diagnosis reached 0.82 (CI = 0.75-0.90), with best model providing sensitivity of 65% and specificity of 92%. Neither TREC, nor KREC had added value in PID group III diagnosis. In this study, the predictive value of TREC and KREC in PID diagnosis was examined. We found that the TREC had some diagnostic utility for groups I and II PID. Possibly, addition of TREC measurements to existing clinical diagnostic algorithms may improve their predictive value. Further investigations on a larger cohort are needed to evaluate TREC/KREC abilities to be used as diagnostic tools on a wider scale.",
keywords = "KREC, PID, TREC, primary immunodeficiency diseases, primary immunodeficiency diseases diagnosis",
author = "Ilya Korsunskiy and Oleg Blyuss and Maria Gordukova and Nataliia Davydova and Alexey Zaikin and Nataliia Zinovieva and Sergey Zimin and Robert Molchanov and Aminat Salpagarova and Maxim Filipenko and Alina Eremeeva and Andrey Prodeus and Anatoliy Korsunskiy and Peter Hsu and Daniel Munblit",
note = "Copyright {\textcopyright} 2020 Korsunskiy, Blyuss, Gordukova, Davydova, Zaikin, Zinovieva, Zimin, Molchanov, Salpagarova, Eremeeva, Filipenko, Prodeus, Korsunskiy, Hsu and Munblit.",
year = "2020",
month = mar,
day = "3",
doi = "10.3389/fimmu.2020.00320",
language = "English",
volume = "11",
pages = "320",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Expanding TREC and KREC Utility in Primary Immunodeficiency Diseases Diagnosis

AU - Korsunskiy, Ilya

AU - Blyuss, Oleg

AU - Gordukova, Maria

AU - Davydova, Nataliia

AU - Zaikin, Alexey

AU - Zinovieva, Nataliia

AU - Zimin, Sergey

AU - Molchanov, Robert

AU - Salpagarova, Aminat

AU - Filipenko, Maxim

AU - Eremeeva, Alina

AU - Prodeus, Andrey

AU - Korsunskiy, Anatoliy

AU - Hsu, Peter

AU - Munblit, Daniel

N1 - Copyright © 2020 Korsunskiy, Blyuss, Gordukova, Davydova, Zaikin, Zinovieva, Zimin, Molchanov, Salpagarova, Eremeeva, Filipenko, Prodeus, Korsunskiy, Hsu and Munblit.

PY - 2020/3/3

Y1 - 2020/3/3

N2 - Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific symptoms. This study aimed to assess TREC and KREC diagnostic ability in PID. Data from children assessed by clinical immunologists at Speransky Children's Hospital, Moscow, Russia with suspected immunodeficiencies were analyzed between May 2013 and August 2016. Peripheral blood samples were sent for TREC/KREC, flow cytometry (CD3, CD4, CD8 and CD19), IgA and IgG analysis. A total of 434 children [189 healthy, 97 with group I and II PID (combined T and B cell immunodeficiencies & well-defined syndromes with immunodeficiency) and 148 group III PID (predominantly antibody deficiencies)] were included. Area under the curve (AUC) for TREC in PID groups I and II diagnosis reached 0.82 (CI = 0.75-0.90), with best model providing sensitivity of 65% and specificity of 92%. Neither TREC, nor KREC had added value in PID group III diagnosis. In this study, the predictive value of TREC and KREC in PID diagnosis was examined. We found that the TREC had some diagnostic utility for groups I and II PID. Possibly, addition of TREC measurements to existing clinical diagnostic algorithms may improve their predictive value. Further investigations on a larger cohort are needed to evaluate TREC/KREC abilities to be used as diagnostic tools on a wider scale.

AB - Primary immunodeficiency diseases (PID) area heterogeneous group of disorders caused by genetic defects of the immune system, which manifest clinically as recurrent infections, autoimmune diseases or malignancies. Early detection of PID remains a challenge, particularly in older children with milder and less specific symptoms. This study aimed to assess TREC and KREC diagnostic ability in PID. Data from children assessed by clinical immunologists at Speransky Children's Hospital, Moscow, Russia with suspected immunodeficiencies were analyzed between May 2013 and August 2016. Peripheral blood samples were sent for TREC/KREC, flow cytometry (CD3, CD4, CD8 and CD19), IgA and IgG analysis. A total of 434 children [189 healthy, 97 with group I and II PID (combined T and B cell immunodeficiencies & well-defined syndromes with immunodeficiency) and 148 group III PID (predominantly antibody deficiencies)] were included. Area under the curve (AUC) for TREC in PID groups I and II diagnosis reached 0.82 (CI = 0.75-0.90), with best model providing sensitivity of 65% and specificity of 92%. Neither TREC, nor KREC had added value in PID group III diagnosis. In this study, the predictive value of TREC and KREC in PID diagnosis was examined. We found that the TREC had some diagnostic utility for groups I and II PID. Possibly, addition of TREC measurements to existing clinical diagnostic algorithms may improve their predictive value. Further investigations on a larger cohort are needed to evaluate TREC/KREC abilities to be used as diagnostic tools on a wider scale.

KW - KREC

KW - PID

KW - TREC

KW - primary immunodeficiency diseases

KW - primary immunodeficiency diseases diagnosis

UR - http://www.scopus.com/inward/record.url?scp=85082052503&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2020.00320

DO - 10.3389/fimmu.2020.00320

M3 - Article

C2 - 32194560

VL - 11

SP - 320

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 320

ER -