University of Hertfordshire

Eyeing up the Future of the Pupillary Light Reflex in Neurodiagnostics

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Eyeing up the Future of the Pupillary Light Reflex in Neurodiagnostics. / Hall, Charlotte; Chilcott, Robert.

In: Diagnostics (Basel, Switzerland), Vol. 8, No. 1, 19, 13.03.2018.

Research output: Contribution to journalReview articlepeer-review

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@article{676548ae07eb4a8491c7e103ed4f3860,
title = "Eyeing up the Future of the Pupillary Light Reflex in Neurodiagnostics",
abstract = "The pupillary light reflex (PLR) describes the constriction and subsequent dilation of the pupil in response to light as a result of the antagonistic actions of the iris sphincter and dilator muscles. Since these muscles are innervated by the parasympathetic and sympathetic nervous systems, respectively, different parameters of the PLR can be used as indicators for either sympathetic or parasympathetic modulation. Thus, the PLR provides an important metric of autonomic nervous system function that has been exploited for a wide range of clinical applications. Measurement of the PLR using dynamic pupillometry is now an established quantitative, non-invasive tool in assessment of traumatic head injuries. This review examines the more recent application of dynamic pupillometry as a diagnostic tool for a wide range of clinical conditions, varying from neurodegenerative disease to exposure to toxic chemicals, as well as its potential in the non-invasive diagnosis of infectious disease.",
keywords = "pupillometry, acetylcholine, cholinergic system, neurodegeneration, trauma, infection, recreational drugs, chemicals, toxins, autism, Journal Article, Review",
author = "Charlotte Hall and Robert Chilcott",
note = "This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",
year = "2018",
month = mar,
day = "13",
doi = "10.3390/diagnostics8010019",
language = "English",
volume = "8",
journal = "Diagnostics (Basel, Switzerland)",
issn = "2075-4418",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - Eyeing up the Future of the Pupillary Light Reflex in Neurodiagnostics

AU - Hall, Charlotte

AU - Chilcott, Robert

N1 - This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2018/3/13

Y1 - 2018/3/13

N2 - The pupillary light reflex (PLR) describes the constriction and subsequent dilation of the pupil in response to light as a result of the antagonistic actions of the iris sphincter and dilator muscles. Since these muscles are innervated by the parasympathetic and sympathetic nervous systems, respectively, different parameters of the PLR can be used as indicators for either sympathetic or parasympathetic modulation. Thus, the PLR provides an important metric of autonomic nervous system function that has been exploited for a wide range of clinical applications. Measurement of the PLR using dynamic pupillometry is now an established quantitative, non-invasive tool in assessment of traumatic head injuries. This review examines the more recent application of dynamic pupillometry as a diagnostic tool for a wide range of clinical conditions, varying from neurodegenerative disease to exposure to toxic chemicals, as well as its potential in the non-invasive diagnosis of infectious disease.

AB - The pupillary light reflex (PLR) describes the constriction and subsequent dilation of the pupil in response to light as a result of the antagonistic actions of the iris sphincter and dilator muscles. Since these muscles are innervated by the parasympathetic and sympathetic nervous systems, respectively, different parameters of the PLR can be used as indicators for either sympathetic or parasympathetic modulation. Thus, the PLR provides an important metric of autonomic nervous system function that has been exploited for a wide range of clinical applications. Measurement of the PLR using dynamic pupillometry is now an established quantitative, non-invasive tool in assessment of traumatic head injuries. This review examines the more recent application of dynamic pupillometry as a diagnostic tool for a wide range of clinical conditions, varying from neurodegenerative disease to exposure to toxic chemicals, as well as its potential in the non-invasive diagnosis of infectious disease.

KW - pupillometry

KW - acetylcholine

KW - cholinergic system

KW - neurodegeneration

KW - trauma

KW - infection

KW - recreational drugs

KW - chemicals

KW - toxins

KW - autism

KW - Journal Article

KW - Review

U2 - 10.3390/diagnostics8010019

DO - 10.3390/diagnostics8010019

M3 - Review article

C2 - 29534018

VL - 8

JO - Diagnostics (Basel, Switzerland)

JF - Diagnostics (Basel, Switzerland)

SN - 2075-4418

IS - 1

M1 - 19

ER -