University of Hertfordshire

By the same authors

In Vitro Cell Models for Ophthalmic Drug Development Applications

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Original languageEnglish
Pages (from-to)94-108
JournalBioResearch Open Access
Publication statusPublished - 20 Apr 2016


Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development
of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular
medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.


© Sara Shafaie et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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