University of Hertfordshire

From the same journal

By the same authors

Indirect Vibration of the Upper Limbs Alters Transmission Along Spinal but Not Corticospinal Pathways

Research output: Contribution to journalArticlepeer-review

Standard

Indirect Vibration of the Upper Limbs Alters Transmission Along Spinal but Not Corticospinal Pathways. / Barss, Trevor; Collins, Dave; Miller, Dylan; Pujari, Amit.

In: Frontiers in Human Neuroscience, Vol. 15, 617669, 17.05.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{e239b0d102d546b097ee6bc090b50be9,
title = "Indirect Vibration of the Upper Limbs Alters Transmission Along Spinal but Not Corticospinal Pathways",
abstract = "The use of upper limb vibration (ULV) during exercise and rehabilitation continues to gain popularity as a modality to improve function and performance. Currently, a lack of knowledge of the pathways being altered during ULV limits its effective implementation. Therefore, the aim of this study was to investigate whether indirect ULV modulates transmission along spinal and corticospinal pathways that control the human forearm. All measures were assessed under CONTROL (no vibration) and ULV (30 Hz; 0.4 mm displacement) conditions while participants maintained a small contraction of the right flexor carpi radialis (FCR) muscle. To assess spinal pathways, Hoffmann reflexes (H-reflexes) elicited by stimulation of the median nerve were recorded from FCR with motor response (M-wave) amplitudes matched between conditions. An H-reflex conditioning paradigm was also used to assess changes in presynaptic inhibition by stimulating the superficial radial (SR) nerve (5 pulses at 300Hz) 37 ms prior to median nerve stimulation. Cutaneous reflexes in FCR elicited by stimulation of the SR nerve at the wrist were also recorded. To assess corticospinal pathways, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation of the contralateral motor cortex were recorded from the right FCR and biceps brachii (BB). ULV significantly reduced H-reflex amplitude by 15.7% for both conditioned and unconditioned reflexes (24.0 ± 15.7 vs. 18.4 ± 11.2% Mmax; p < 0.05). Middle latency cutaneous reflexes were also significantly reduced by 20.0% from CONTROL (−1.50 ± 2.1% Mmax) to ULV (−1.73 ± 2.2% Mmax; p < 0.05). There was no significant effect of ULV on MEP amplitude (p > 0.05). Therefore, ULV inhibits cutaneous and H-reflex transmission without influencing corticospinal excitability of the forearm flexors suggesting increased presynaptic inhibition of afferent transmission as a likely mechanism. A general increase in inhibition of spinal pathways with ULV may have important implications for improving rehabilitation for individuals with spasticity (SCI, stroke, MS, etc.).",
keywords = "H-reflex, cutaneous reflex, electromyography, indirect vibration, motor evoked potential, sensorimotor integration, transcranial magnetic stimulation, upper limb vibration",
author = "Trevor Barss and Dave Collins and Dylan Miller and Amit Pujari",
note = "Funding Information: Support for this research was provided by the Churchill Travelling Fellowship through Winston Churchill Memorial Trust (to AP) and a Campus Alberta Neuroscience Postdoctoral Fellowship (TB). The vibration stimulation device used in this work was supported by funding from the Scottish Funding Council, United Kingdom (SFC) (to AP). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Barss, Collins, Miller and Pujari.",
year = "2021",
month = may,
day = "17",
doi = "10.3389/fnhum.2021.617669",
language = "English",
volume = "15",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Indirect Vibration of the Upper Limbs Alters Transmission Along Spinal but Not Corticospinal Pathways

AU - Barss, Trevor

AU - Collins, Dave

AU - Miller, Dylan

AU - Pujari, Amit

N1 - Funding Information: Support for this research was provided by the Churchill Travelling Fellowship through Winston Churchill Memorial Trust (to AP) and a Campus Alberta Neuroscience Postdoctoral Fellowship (TB). The vibration stimulation device used in this work was supported by funding from the Scottish Funding Council, United Kingdom (SFC) (to AP). Publisher Copyright: © Copyright © 2021 Barss, Collins, Miller and Pujari.

PY - 2021/5/17

Y1 - 2021/5/17

N2 - The use of upper limb vibration (ULV) during exercise and rehabilitation continues to gain popularity as a modality to improve function and performance. Currently, a lack of knowledge of the pathways being altered during ULV limits its effective implementation. Therefore, the aim of this study was to investigate whether indirect ULV modulates transmission along spinal and corticospinal pathways that control the human forearm. All measures were assessed under CONTROL (no vibration) and ULV (30 Hz; 0.4 mm displacement) conditions while participants maintained a small contraction of the right flexor carpi radialis (FCR) muscle. To assess spinal pathways, Hoffmann reflexes (H-reflexes) elicited by stimulation of the median nerve were recorded from FCR with motor response (M-wave) amplitudes matched between conditions. An H-reflex conditioning paradigm was also used to assess changes in presynaptic inhibition by stimulating the superficial radial (SR) nerve (5 pulses at 300Hz) 37 ms prior to median nerve stimulation. Cutaneous reflexes in FCR elicited by stimulation of the SR nerve at the wrist were also recorded. To assess corticospinal pathways, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation of the contralateral motor cortex were recorded from the right FCR and biceps brachii (BB). ULV significantly reduced H-reflex amplitude by 15.7% for both conditioned and unconditioned reflexes (24.0 ± 15.7 vs. 18.4 ± 11.2% Mmax; p < 0.05). Middle latency cutaneous reflexes were also significantly reduced by 20.0% from CONTROL (−1.50 ± 2.1% Mmax) to ULV (−1.73 ± 2.2% Mmax; p < 0.05). There was no significant effect of ULV on MEP amplitude (p > 0.05). Therefore, ULV inhibits cutaneous and H-reflex transmission without influencing corticospinal excitability of the forearm flexors suggesting increased presynaptic inhibition of afferent transmission as a likely mechanism. A general increase in inhibition of spinal pathways with ULV may have important implications for improving rehabilitation for individuals with spasticity (SCI, stroke, MS, etc.).

AB - The use of upper limb vibration (ULV) during exercise and rehabilitation continues to gain popularity as a modality to improve function and performance. Currently, a lack of knowledge of the pathways being altered during ULV limits its effective implementation. Therefore, the aim of this study was to investigate whether indirect ULV modulates transmission along spinal and corticospinal pathways that control the human forearm. All measures were assessed under CONTROL (no vibration) and ULV (30 Hz; 0.4 mm displacement) conditions while participants maintained a small contraction of the right flexor carpi radialis (FCR) muscle. To assess spinal pathways, Hoffmann reflexes (H-reflexes) elicited by stimulation of the median nerve were recorded from FCR with motor response (M-wave) amplitudes matched between conditions. An H-reflex conditioning paradigm was also used to assess changes in presynaptic inhibition by stimulating the superficial radial (SR) nerve (5 pulses at 300Hz) 37 ms prior to median nerve stimulation. Cutaneous reflexes in FCR elicited by stimulation of the SR nerve at the wrist were also recorded. To assess corticospinal pathways, motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation of the contralateral motor cortex were recorded from the right FCR and biceps brachii (BB). ULV significantly reduced H-reflex amplitude by 15.7% for both conditioned and unconditioned reflexes (24.0 ± 15.7 vs. 18.4 ± 11.2% Mmax; p < 0.05). Middle latency cutaneous reflexes were also significantly reduced by 20.0% from CONTROL (−1.50 ± 2.1% Mmax) to ULV (−1.73 ± 2.2% Mmax; p < 0.05). There was no significant effect of ULV on MEP amplitude (p > 0.05). Therefore, ULV inhibits cutaneous and H-reflex transmission without influencing corticospinal excitability of the forearm flexors suggesting increased presynaptic inhibition of afferent transmission as a likely mechanism. A general increase in inhibition of spinal pathways with ULV may have important implications for improving rehabilitation for individuals with spasticity (SCI, stroke, MS, etc.).

KW - H-reflex

KW - cutaneous reflex

KW - electromyography

KW - indirect vibration

KW - motor evoked potential

KW - sensorimotor integration

KW - transcranial magnetic stimulation

KW - upper limb vibration

UR - http://www.scopus.com/inward/record.url?scp=85107046853&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2021.617669

DO - 10.3389/fnhum.2021.617669

M3 - Article

VL - 15

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 617669

ER -