University of Hertfordshire

Interactions of inhaled drugs with active transport mechanisms in bronchial epithelial cell layers in vitro

Research output: Contribution to conferenceAbstractpeer-review

  • Victoria Hutter
  • Constanze Hilgendorf
  • Vanessa Zann
  • Anne Cooper
  • David Pritchard
  • Cynthia Bosquillon
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Original languageEnglish
Publication statusPublished - 2012
EventUK PharmSci 2012 - Nottingham, United Kingdom
Duration: 12 Sep 201214 Sep 2012


ConferenceUK PharmSci 2012
Country/TerritoryUnited Kingdom


The transport of 3H-digoxin (an established MDR1 and OATP substrate) was assessed alone, and in the presence of marketed inhaled drug compounds in Calu-3 cell monolayers cultured at an air-liquid interface for 21 days. Net secretory transport of 3H-digoxin was significantly reduced (p<0.01) in the presence of both budesonide and formoterol but not in the presence of salbutamol. Results suggest that therapeutically relevant concentrations of marketed inhaled drugs might interact with drug transporters in the bronchial epithelium

ID: 1042319