University of Hertfordshire


  • Annemie Deiteren
  • Joris de Man
  • Christopher Keating
  • Wen Jiang
  • Heiko de Schepper
  • Paul Pelckmans
  • Sven Francque
  • Benedicte de Winter
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Original languageEnglish
Pages (from-to)1709-1720
JournalNeurogastroenterology and Motility
Early online date4 Sep 2015
Publication statusPublished - 19 Nov 2015


Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.


This is the peer reviewed version of the following article: Deiteren, A., De Man, J. G., Keating, C., Jiang, W., De Schepper, H. U., Pelckmans, P. A., Francque, S. M. and De Winter, B. Y. (2015), Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling. Neurogastroenterology & Motility, 27: 1709–1720, which has been published in final form at doi:10.1111/nmo.12667. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

ID: 8735206