University of Hertfordshire

From the same journal

By the same authors

Standard

Method Development for the Determination of Elements in Hypericum perforatum L. (St John’s wort) Herb and Preparations using ICP-OES and Microwave Digestion. / Owen, Jade; Evans, Sara; Guirguis, Amira; Kellett, Kathryn; Stair, Jacqueline.

In: Journal of Pharmacy and Pharmacology, 31.05.2017.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{0eae79edcbff4b38b3fc1aa0e7aa85db,
title = "Method Development for the Determination of Elements in Hypericum perforatum L. (St John{\textquoteright}s wort) Herb and Preparations using ICP-OES and Microwave Digestion",
abstract = "Objectives: A method was developed to analyze St John's wort (Hypericum perforatum L.) herb and preparations using inductively coupled plasma-optical emission spectroscopy (ICP-OES) to determine the quantity of 11 elements (Al, B, Ba, Ca, Cu, Fe, Mg, Mn, Ni, Sr and Zn). Methods: This study includes the evaluation of digestion acids and calibration methods, as well as instrumental parameters such as choice of nebulizer and emission wavelength. Key findings: Two nebulizers (Conikal and SeaSpray) performed similarly for most elements, and two optimum wavelengths were determined for each element. Five acids were evaluated for the digestion of the Polish Certified Reference Material Tea Leaves (INCT-TL-1), while three were taken forward to use for the different St John's wort formulations (i.e. herb, capsule and tablet). A simple protocol using 5 ml HNO3 was sufficient in most cases; however, variability was observed for elements often bound in silicates (e.g. Al, Fe and Zn). An external weighted calibration was also found to be preferential over unweighted, and the use of standard addition affected some concentration values up to 20%. Conclusions: Therefore, this paper presents the development and optimized method parameters to be used with ICP-OES that will allow the analysis of 11 key elements present in St John's wort herb and preparations.",
keywords = "Hypericum perforatum L., ICP-OES, element, St John's wort, method development",
author = "Jade Owen and Sara Evans and Amira Guirguis and Kathryn Kellett and Jacqueline Stair",
note = "This is the peer reviewed version of the following article: Owen, J. D., Evans, S. J., Guirguis, A., Kellett, K. and Stair, J. L. (2017), 'Method development for the determination of elements in Hypericum perforatum L. (St John's wort) herb and preparations using inductively coupled plasma–optical emission', which has been published in final form at doi: 10.1111/jphp.12742 . Under embargo. Embargo end date: 31 May 2018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",
year = "2017",
month = may,
day = "31",
doi = "10.1111/jphp.12742",
language = "English",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",

}

RIS

TY - JOUR

T1 - Method Development for the Determination of Elements in Hypericum perforatum L. (St John’s wort) Herb and Preparations using ICP-OES and Microwave Digestion

AU - Owen, Jade

AU - Evans, Sara

AU - Guirguis, Amira

AU - Kellett, Kathryn

AU - Stair, Jacqueline

N1 - This is the peer reviewed version of the following article: Owen, J. D., Evans, S. J., Guirguis, A., Kellett, K. and Stair, J. L. (2017), 'Method development for the determination of elements in Hypericum perforatum L. (St John's wort) herb and preparations using inductively coupled plasma–optical emission', which has been published in final form at doi: 10.1111/jphp.12742 . Under embargo. Embargo end date: 31 May 2018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2017/5/31

Y1 - 2017/5/31

N2 - Objectives: A method was developed to analyze St John's wort (Hypericum perforatum L.) herb and preparations using inductively coupled plasma-optical emission spectroscopy (ICP-OES) to determine the quantity of 11 elements (Al, B, Ba, Ca, Cu, Fe, Mg, Mn, Ni, Sr and Zn). Methods: This study includes the evaluation of digestion acids and calibration methods, as well as instrumental parameters such as choice of nebulizer and emission wavelength. Key findings: Two nebulizers (Conikal and SeaSpray) performed similarly for most elements, and two optimum wavelengths were determined for each element. Five acids were evaluated for the digestion of the Polish Certified Reference Material Tea Leaves (INCT-TL-1), while three were taken forward to use for the different St John's wort formulations (i.e. herb, capsule and tablet). A simple protocol using 5 ml HNO3 was sufficient in most cases; however, variability was observed for elements often bound in silicates (e.g. Al, Fe and Zn). An external weighted calibration was also found to be preferential over unweighted, and the use of standard addition affected some concentration values up to 20%. Conclusions: Therefore, this paper presents the development and optimized method parameters to be used with ICP-OES that will allow the analysis of 11 key elements present in St John's wort herb and preparations.

AB - Objectives: A method was developed to analyze St John's wort (Hypericum perforatum L.) herb and preparations using inductively coupled plasma-optical emission spectroscopy (ICP-OES) to determine the quantity of 11 elements (Al, B, Ba, Ca, Cu, Fe, Mg, Mn, Ni, Sr and Zn). Methods: This study includes the evaluation of digestion acids and calibration methods, as well as instrumental parameters such as choice of nebulizer and emission wavelength. Key findings: Two nebulizers (Conikal and SeaSpray) performed similarly for most elements, and two optimum wavelengths were determined for each element. Five acids were evaluated for the digestion of the Polish Certified Reference Material Tea Leaves (INCT-TL-1), while three were taken forward to use for the different St John's wort formulations (i.e. herb, capsule and tablet). A simple protocol using 5 ml HNO3 was sufficient in most cases; however, variability was observed for elements often bound in silicates (e.g. Al, Fe and Zn). An external weighted calibration was also found to be preferential over unweighted, and the use of standard addition affected some concentration values up to 20%. Conclusions: Therefore, this paper presents the development and optimized method parameters to be used with ICP-OES that will allow the analysis of 11 key elements present in St John's wort herb and preparations.

KW - Hypericum perforatum L.

KW - ICP-OES

KW - element

KW - St John's wort

KW - method development

U2 - 10.1111/jphp.12742

DO - 10.1111/jphp.12742

M3 - Article

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

ER -