University of Hertfordshire

From the same journal

By the same authors

Misuse of anticholinergic medications: a systematic review.

Research output: Contribution to journalReview articlepeer-review

Standard

Misuse of anticholinergic medications: a systematic review. / Chiappini, Stefania; Mosca, Alessio; Miuli, Andrea; Semeraro, Francesco; Mancusi, Gianluca; Santovito, Maria Chiara ; Di Carlo, Francesco; Pettorruso, Mauro; Guirguis, Amira; Corkery, John M.; Martinotti, Giovanni; Schifano, Fabrizio; di Giannantonio, Massimo.

In: Biomedicines, Vol. 10, No. 2, 355, 01.02.2022.

Research output: Contribution to journalReview articlepeer-review

Harvard

Chiappini, S, Mosca, A, Miuli, A, Semeraro, F, Mancusi, G, Santovito, MC, Di Carlo, F, Pettorruso, M, Guirguis, A, Corkery, JM, Martinotti, G, Schifano, F & di Giannantonio, M 2022, 'Misuse of anticholinergic medications: a systematic review.', Biomedicines, vol. 10, no. 2, 355. https://doi.org/10.3390/biomedicines10020355

APA

Chiappini, S., Mosca, A., Miuli, A., Semeraro, F., Mancusi, G., Santovito, M. C., Di Carlo, F., Pettorruso, M., Guirguis, A., Corkery, J. M., Martinotti, G., Schifano, F., & di Giannantonio, M. (2022). Misuse of anticholinergic medications: a systematic review. Biomedicines, 10(2), [355]. https://doi.org/10.3390/biomedicines10020355

Vancouver

Chiappini S, Mosca A, Miuli A, Semeraro F, Mancusi G, Santovito MC et al. Misuse of anticholinergic medications: a systematic review. Biomedicines. 2022 Feb 1;10(2). 355. https://doi.org/10.3390/biomedicines10020355

Author

Chiappini, Stefania ; Mosca, Alessio ; Miuli, Andrea ; Semeraro, Francesco ; Mancusi, Gianluca ; Santovito, Maria Chiara ; Di Carlo, Francesco ; Pettorruso, Mauro ; Guirguis, Amira ; Corkery, John M. ; Martinotti, Giovanni ; Schifano, Fabrizio ; di Giannantonio, Massimo. / Misuse of anticholinergic medications: a systematic review. In: Biomedicines. 2022 ; Vol. 10, No. 2.

Bibtex

@article{bf43c615cdd042a6b571b4c9e61d5edd,
title = "Misuse of anticholinergic medications: a systematic review.",
abstract = "(1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (n = 25), and benztropine (n = 4). The routes of administration were mostly oral, and macrodoses together concomitant illicit drugs, e.g., cocaine, have been recorded. Toxidromes included both physical (e.g., tachycardia, tachypnoea, dilatated pupils, dry skin, urinary retention, ataxia, etc.) and psychiatric symptoms (e.g., anxiety, agitation, delirium, etc.). Fatal outcomes were very rare but reported. (4) Conclusion: Results from the present study show that anticholinergic misusing issues are both widespread worldwide and popular. Considering the potential adverse effects associated, healthcare professionals should be vigilant and monitor eventual misusing issues.",
keywords = "Anticholinergic drugs, Drug abuse, Drug diversion, Drug misuse",
author = "Stefania Chiappini and Alessio Mosca and Andrea Miuli and Francesco Semeraro and Gianluca Mancusi and Santovito, {Maria Chiara} and {Di Carlo}, Francesco and Mauro Pettorruso and Amira Guirguis and Corkery, {John M.} and Giovanni Martinotti and Fabrizio Schifano and {di Giannantonio}, Massimo",
note = "{\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) ",
year = "2022",
month = feb,
day = "1",
doi = "10.3390/biomedicines10020355",
language = "English",
volume = "10",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Misuse of anticholinergic medications: a systematic review.

AU - Chiappini, Stefania

AU - Mosca, Alessio

AU - Miuli, Andrea

AU - Semeraro, Francesco

AU - Mancusi, Gianluca

AU - Santovito, Maria Chiara

AU - Di Carlo, Francesco

AU - Pettorruso, Mauro

AU - Guirguis, Amira

AU - Corkery, John M.

AU - Martinotti, Giovanni

AU - Schifano, Fabrizio

AU - di Giannantonio, Massimo

N1 - © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)

PY - 2022/2/1

Y1 - 2022/2/1

N2 - (1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (n = 25), and benztropine (n = 4). The routes of administration were mostly oral, and macrodoses together concomitant illicit drugs, e.g., cocaine, have been recorded. Toxidromes included both physical (e.g., tachycardia, tachypnoea, dilatated pupils, dry skin, urinary retention, ataxia, etc.) and psychiatric symptoms (e.g., anxiety, agitation, delirium, etc.). Fatal outcomes were very rare but reported. (4) Conclusion: Results from the present study show that anticholinergic misusing issues are both widespread worldwide and popular. Considering the potential adverse effects associated, healthcare professionals should be vigilant and monitor eventual misusing issues.

AB - (1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (n = 25), and benztropine (n = 4). The routes of administration were mostly oral, and macrodoses together concomitant illicit drugs, e.g., cocaine, have been recorded. Toxidromes included both physical (e.g., tachycardia, tachypnoea, dilatated pupils, dry skin, urinary retention, ataxia, etc.) and psychiatric symptoms (e.g., anxiety, agitation, delirium, etc.). Fatal outcomes were very rare but reported. (4) Conclusion: Results from the present study show that anticholinergic misusing issues are both widespread worldwide and popular. Considering the potential adverse effects associated, healthcare professionals should be vigilant and monitor eventual misusing issues.

KW - Anticholinergic drugs

KW - Drug abuse

KW - Drug diversion

KW - Drug misuse

UR - http://www.scopus.com/inward/record.url?scp=85124250787&partnerID=8YFLogxK

U2 - 10.3390/biomedicines10020355

DO - 10.3390/biomedicines10020355

M3 - Review article

C2 - 35203563

VL - 10

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 2

M1 - 355

ER -