University of Hertfordshire

By the same authors

Open-access high-resolution mass spectrometry in early drug discovery

Research output: Contribution to journalArticlepeer-review

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Original languageEnglish
Pages (from-to)942-948
Number of pages7
JournalJournal of Mass Spectrometry
Publication statusPublished - Aug 2004


Techniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early insight into their reaction products has a direct impact on productivity. Devolution of cutting-edge techniques from the specialist to the bench chemist also frees the specialist to concentrate on solving the more demanding of analytical problems. For open-access techniques to be taken up, they must be robust and be able to handle differing sample concentrations and varying sample complexities. This paper details the implementation of high-resolution liquid chromatography/mass spectrometry in open access to aid the medicinal chemist in characterizing desired products and identifying unexpected rearrangements, by-products and complete unknowns. Copyright (C) 2004 John Wiley Sons, Ltd.

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