University of Hertfordshire

Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines

Research output: Contribution to conferencePosterpeer-review

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Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines. / Styliari, Ioanna Danai; Mobli, Arian; Murnane, Darragh.

2018. Poster session presented at Drug Delivery to the Lungs 2018, Edinburgh, United Kingdom.

Research output: Contribution to conferencePosterpeer-review

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Styliari ID, Mobli A, Murnane D. Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines. 2018. Poster session presented at Drug Delivery to the Lungs 2018, Edinburgh, United Kingdom.

Author

Styliari, Ioanna Danai ; Mobli, Arian ; Murnane, Darragh. / Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines. Poster session presented at Drug Delivery to the Lungs 2018, Edinburgh, United Kingdom.

Bibtex

@conference{4c24adf1443a4b44bb60cac17c7eaa8d,
title = "Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines",
abstract = "Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. As a first step towards this investigation, “clean” lactose, with removed fines, was produced via wet decantation. Ethanol and isopropyl alcohol have been used in wet decantation, successfully removing lactose fines from the surface of the coarse particles. Differential Scanning Calorimetry (DSC) was employed to show that the powders maintained their crystalline character. Scanning Electron Microscopy (SEM) showed tomahawk-shaped particles in all the powders and some surface alteration occurring after decantation. An airflow titration method using laser diffraction (LDA) allowed the estimation of the removal of fines as well as the particle size distributions, while the non-polar and the polar components of the surface energy of the powders were calculated via Inverse Gas Chromatography-Surface Energy Analysis (iGC-SEA). As both solvents successfully removed fines, we propose the addition of isopropyl alcohol in the list of organic solvents suitable for this purpose.",
author = "Styliari, {Ioanna Danai} and Arian Mobli and Darragh Murnane",
year = "2018",
month = dec,
day = "14",
language = "English",
note = "Drug Delivery to the Lungs 2018, DDL2018 ; Conference date: 12-12-2018 Through 14-12-2018",

}

RIS

TY - CONF

T1 - Physicochemical characterisation of inhalation grade lactose after the removal of intrinsic fines

AU - Styliari, Ioanna Danai

AU - Mobli, Arian

AU - Murnane, Darragh

N1 - Conference code: 29

PY - 2018/12/14

Y1 - 2018/12/14

N2 - Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. As a first step towards this investigation, “clean” lactose, with removed fines, was produced via wet decantation. Ethanol and isopropyl alcohol have been used in wet decantation, successfully removing lactose fines from the surface of the coarse particles. Differential Scanning Calorimetry (DSC) was employed to show that the powders maintained their crystalline character. Scanning Electron Microscopy (SEM) showed tomahawk-shaped particles in all the powders and some surface alteration occurring after decantation. An airflow titration method using laser diffraction (LDA) allowed the estimation of the removal of fines as well as the particle size distributions, while the non-polar and the polar components of the surface energy of the powders were calculated via Inverse Gas Chromatography-Surface Energy Analysis (iGC-SEA). As both solvents successfully removed fines, we propose the addition of isopropyl alcohol in the list of organic solvents suitable for this purpose.

AB - Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. As a first step towards this investigation, “clean” lactose, with removed fines, was produced via wet decantation. Ethanol and isopropyl alcohol have been used in wet decantation, successfully removing lactose fines from the surface of the coarse particles. Differential Scanning Calorimetry (DSC) was employed to show that the powders maintained their crystalline character. Scanning Electron Microscopy (SEM) showed tomahawk-shaped particles in all the powders and some surface alteration occurring after decantation. An airflow titration method using laser diffraction (LDA) allowed the estimation of the removal of fines as well as the particle size distributions, while the non-polar and the polar components of the surface energy of the powders were calculated via Inverse Gas Chromatography-Surface Energy Analysis (iGC-SEA). As both solvents successfully removed fines, we propose the addition of isopropyl alcohol in the list of organic solvents suitable for this purpose.

UR - https://aerosol-soc.com/events/ddl2018/

M3 - Poster

T2 - Drug Delivery to the Lungs 2018

Y2 - 12 December 2018 through 14 December 2018

ER -