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Precision treatment in ACS – role of assessing fibrinolysis

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Precision treatment in ACS – role of assessing fibrinolysis. / Gue, Ying X.; Jeong, Young-Hoon; Farag, Mohamed et al.

In: Journal of Clinical Medicine, Vol. 10, No. 5, 929, 01.03.2021.

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Gue, Ying X. ; Jeong, Young-Hoon ; Farag, Mohamed et al. / Precision treatment in ACS – role of assessing fibrinolysis. In: Journal of Clinical Medicine. 2021 ; Vol. 10, No. 5.

Bibtex

@article{9099e8a433f247fe9f84d5c02a2bbac0,
title = "Precision treatment in ACS – role of assessing fibrinolysis",
abstract = "Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, impairment in the ability to naturally dissolve or lyse a developing thrombus, namely impaired endogenous fibrinolysis, is responsible for a major part of this residual risk regardless of optimal antiplatelet medication. Global assessment of endogenous fibrinolysis, including a point-of-care assay, can identify patients with ACS at persistent high cardiovascular risk and might play an important role in allowing the personalisation of potent antithrombotic therapy to enhance fibrinolytic status, providing precision treatment of ACS to improve long-term outcome.",
author = "Gue, {Ying X.} and Young-Hoon Jeong and Mohamed Farag and Nikolaos Spinthakis and Diana Gorog",
note = "{\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).",
year = "2021",
month = mar,
day = "1",
doi = "10.3390/jcm10050929",
language = "English",
volume = "10",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Precision treatment in ACS – role of assessing fibrinolysis

AU - Gue, Ying X.

AU - Jeong, Young-Hoon

AU - Farag, Mohamed

AU - Spinthakis, Nikolaos

AU - Gorog, Diana

N1 - © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, impairment in the ability to naturally dissolve or lyse a developing thrombus, namely impaired endogenous fibrinolysis, is responsible for a major part of this residual risk regardless of optimal antiplatelet medication. Global assessment of endogenous fibrinolysis, including a point-of-care assay, can identify patients with ACS at persistent high cardiovascular risk and might play an important role in allowing the personalisation of potent antithrombotic therapy to enhance fibrinolytic status, providing precision treatment of ACS to improve long-term outcome.

AB - Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, impairment in the ability to naturally dissolve or lyse a developing thrombus, namely impaired endogenous fibrinolysis, is responsible for a major part of this residual risk regardless of optimal antiplatelet medication. Global assessment of endogenous fibrinolysis, including a point-of-care assay, can identify patients with ACS at persistent high cardiovascular risk and might play an important role in allowing the personalisation of potent antithrombotic therapy to enhance fibrinolytic status, providing precision treatment of ACS to improve long-term outcome.

U2 - 10.3390/jcm10050929

DO - 10.3390/jcm10050929

M3 - Article

VL - 10

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 5

M1 - 929

ER -