University of Hertfordshire

From the same journal

By the same authors

Standard

Preliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate). / Matar, Hazem; Guerreiro, Antonio; Piletsky, Sergey A.; Price, Shirley; Chilcott, Robert.

In: Cutaneous and Ocular Toxicology, Vol. 35, No. 2, 02.04.2016, p. 137-144.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{bb3df2a5d21844a99f41d3c47d1ec3e3,
title = "Preliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate)",
abstract = "Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or military products and 5 were novel (molecular imprinted) polymers. The efficacies of these products were evaluated against a 10µL droplet of 14C-methyl salicylate applied to the surface of porcine skin mounted on static diffusion cells. The current UK military decontaminant (Fuller{\textquoteright}s earth) performed well, retaining 83% of the dose over 24 hours and served as a benchmark to compare with the other test products. The five most effective test products were Fuller{\textquoteright}s earth (the current UK military decontaminant), Fast-Act{\textregistered} and three novel polymers (based on itaconic acid, 2-trifluoromethylacrylic acid and N,N-methylene bis acrylamide). Five products (medical moist free wipes, 5% FloraFree{\texttrademark} solution, normal baby wipes, baby wipes for sensitive skin and Diphot{\'e}rine{\texttrademark}) enhanced the dermal absorption of 14C-methyl salicylate. Further work is required to establish the performance of the most effective products identified in this study against chemical warfare agents.",
keywords = "Absorbent, chemical warfare agent, decontamination, methyl salicylate, percutaneous absorption, skin",
author = "Hazem Matar and Antonio Guerreiro and Piletsky, {Sergey A.} and Shirley Price and Robert Chilcott",
note = "This is an Accepted Manuscript of an article published by Taylor & Francis in Cutaneous and Ocular Toxicology on 13 August 2015, available online: http://www.tandfonline.com/doi/full/10.3109/15569527.2015.1072544.",
year = "2016",
month = apr,
day = "2",
doi = "10.3109/15569527.2015.1072544",
language = "English",
volume = "35",
pages = "137--144",
journal = "Cutaneous and Ocular Toxicology",
issn = "1556-9527",
publisher = "Informa Healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - Preliminary evaluation of military, commercial and novel skin decontamination products against a chemical warfare agent simulant (methyl salicylate)

AU - Matar, Hazem

AU - Guerreiro, Antonio

AU - Piletsky, Sergey A.

AU - Price, Shirley

AU - Chilcott, Robert

N1 - This is an Accepted Manuscript of an article published by Taylor & Francis in Cutaneous and Ocular Toxicology on 13 August 2015, available online: http://www.tandfonline.com/doi/full/10.3109/15569527.2015.1072544.

PY - 2016/4/2

Y1 - 2016/4/2

N2 - Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or military products and 5 were novel (molecular imprinted) polymers. The efficacies of these products were evaluated against a 10µL droplet of 14C-methyl salicylate applied to the surface of porcine skin mounted on static diffusion cells. The current UK military decontaminant (Fuller’s earth) performed well, retaining 83% of the dose over 24 hours and served as a benchmark to compare with the other test products. The five most effective test products were Fuller’s earth (the current UK military decontaminant), Fast-Act® and three novel polymers (based on itaconic acid, 2-trifluoromethylacrylic acid and N,N-methylene bis acrylamide). Five products (medical moist free wipes, 5% FloraFree™ solution, normal baby wipes, baby wipes for sensitive skin and Diphotérine™) enhanced the dermal absorption of 14C-methyl salicylate. Further work is required to establish the performance of the most effective products identified in this study against chemical warfare agents.

AB - Rapid decontamination is vital to alleviate adverse health effects following dermal exposure to hazardous materials. There is an abundance of materials and products which can be utilised to remove hazardous materials from the skin. In this study, a total of 15 products were evaluated, 10 of which were commercial or military products and 5 were novel (molecular imprinted) polymers. The efficacies of these products were evaluated against a 10µL droplet of 14C-methyl salicylate applied to the surface of porcine skin mounted on static diffusion cells. The current UK military decontaminant (Fuller’s earth) performed well, retaining 83% of the dose over 24 hours and served as a benchmark to compare with the other test products. The five most effective test products were Fuller’s earth (the current UK military decontaminant), Fast-Act® and three novel polymers (based on itaconic acid, 2-trifluoromethylacrylic acid and N,N-methylene bis acrylamide). Five products (medical moist free wipes, 5% FloraFree™ solution, normal baby wipes, baby wipes for sensitive skin and Diphotérine™) enhanced the dermal absorption of 14C-methyl salicylate. Further work is required to establish the performance of the most effective products identified in this study against chemical warfare agents.

KW - Absorbent

KW - chemical warfare agent

KW - decontamination

KW - methyl salicylate

KW - percutaneous absorption

KW - skin

U2 - 10.3109/15569527.2015.1072544

DO - 10.3109/15569527.2015.1072544

M3 - Article

C2 - 26339920

VL - 35

SP - 137

EP - 144

JO - Cutaneous and Ocular Toxicology

JF - Cutaneous and Ocular Toxicology

SN - 1556-9527

IS - 2

ER -