University of Hertfordshire

From the same journal

By the same authors

  • Nada Yousif
  • Nicola Pavese
  • Mohammad J Naushahi
  • Dipankar Nandi
  • Peter G Bain
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Original languageEnglish
Pages (from-to)10-17
Number of pages8
Early online date24 Sep 2012
Publication statusPublished - 2 Jan 2014


The quadripolar electrodes used for deep brain stimulation are designed to give flexibility in contact configuration, optimize therapeutic effect, and minimize side-effects. A patient with essential tremor did not tolerate a bipolar setting due to the emergence of a pulling sensation in her face. However, when the polarity of the contacts was reversed, a 70% higher voltage was tolerated. Using an electric field model, we predicted that this effect was due to the proximity of the topmost contact to the internal capsule. Post-operative imaging supported this prediction. These results demonstrate how a multi-disciplinary approach allows us to optimize parameter settings.


Nada Yousif, et al, 'Reversing the polarity of bipolar stimulation in deep brain stimulation for essential tremor: A theoretical explanation for a useful clinical intervention', Neurocase, Vol. 20 (1): 10-17, September 2012, doi:

ID: 10760100