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Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

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Somatic transformation in metastatic testicular germ cell tumours – A different disease entity. / Sharma, Anand; Alifrangis, Constantine; Milic, Marina; Hall, Marcia; Vasdev, Nikhil; Wilson, Peter; Gogbashian, Andrew; Hrouda, David; Berney, Daniel; Shamash, Jonathan.

In: Anticancer Research, Vol. 39, No. 9, 01.09.2019, p. 4911-4916.

Research output: Contribution to journalArticlepeer-review

Harvard

Sharma, A, Alifrangis, C, Milic, M, Hall, M, Vasdev, N, Wilson, P, Gogbashian, A, Hrouda, D, Berney, D & Shamash, J 2019, 'Somatic transformation in metastatic testicular germ cell tumours – A different disease entity', Anticancer Research, vol. 39, no. 9, pp. 4911-4916. https://doi.org/10.21873/anticanres.13678

APA

Sharma, A., Alifrangis, C., Milic, M., Hall, M., Vasdev, N., Wilson, P., Gogbashian, A., Hrouda, D., Berney, D., & Shamash, J. (2019). Somatic transformation in metastatic testicular germ cell tumours – A different disease entity. Anticancer Research, 39(9), 4911-4916. https://doi.org/10.21873/anticanres.13678

Vancouver

Author

Sharma, Anand ; Alifrangis, Constantine ; Milic, Marina ; Hall, Marcia ; Vasdev, Nikhil ; Wilson, Peter ; Gogbashian, Andrew ; Hrouda, David ; Berney, Daniel ; Shamash, Jonathan. / Somatic transformation in metastatic testicular germ cell tumours – A different disease entity. In: Anticancer Research. 2019 ; Vol. 39, No. 9. pp. 4911-4916.

Bibtex

@article{496395a884404a81bcd8aba6d0c76b46,
title = "Somatic transformation in metastatic testicular germ cell tumours – A different disease entity",
abstract = "Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew{\textquoteright}s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.",
keywords = "Germ cell tumour, Immature teratoma, Rhabdomyosarcoma, Sarcoma, Somatic transformation",
author = "Anand Sharma and Constantine Alifrangis and Marina Milic and Marcia Hall and Nikhil Vasdev and Peter Wilson and Andrew Gogbashian and David Hrouda and Daniel Berney and Jonathan Shamash",
note = "Copyright{\textcopyright} 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.",
year = "2019",
month = sep,
day = "1",
doi = "10.21873/anticanres.13678",
language = "English",
volume = "39",
pages = "4911--4916",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",

}

RIS

TY - JOUR

T1 - Somatic transformation in metastatic testicular germ cell tumours – A different disease entity

AU - Sharma, Anand

AU - Alifrangis, Constantine

AU - Milic, Marina

AU - Hall, Marcia

AU - Vasdev, Nikhil

AU - Wilson, Peter

AU - Gogbashian, Andrew

AU - Hrouda, David

AU - Berney, Daniel

AU - Shamash, Jonathan

N1 - Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew’s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

AB - Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew’s Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). Results: The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Conclusion: Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.

KW - Germ cell tumour

KW - Immature teratoma

KW - Rhabdomyosarcoma

KW - Sarcoma

KW - Somatic transformation

UR - http://www.scopus.com/inward/record.url?scp=85072227520&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13678

DO - 10.21873/anticanres.13678

M3 - Article

C2 - 31519595

AN - SCOPUS:85072227520

VL - 39

SP - 4911

EP - 4916

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 9

ER -