University of Hertfordshire


  • 3675_full

    Final published version, 107 KB, PDF document

  • Anand Sharma
  • Deshveer Babra
  • Priya Joshi
  • Marcia Hall
  • Andrew Gogbashian
  • Nikhil Vasdev
  • Magdalene Joseph
  • Amir Yazdan
  • Edward Kanfer
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Original languageEnglish
Pages (from-to)3675-3679
Number of pages5
JournalIn VIVO - International Journal of Experimental and Clinical Pathophysiology and Drug Research
Publication statusPublished - Nov 2020


Background/Aim: High-dose chemotherapy (HDCT) and stem cell transplantation (SCT) have been established as the standard of care in patients with relapsed germ cell tumours (GCTs). We evaluated the safety, efficacy and tolerability of HDCT/ SCT in patients with relapsed GCTs.
Patients and Methods: Twenty-eight patients with relapsed GCTs, treated with HDCT, were included in this study. The conditioning regime was carboplatin, etoposide, cyclophosphamide and paclitaxel. Clinical, radiological imaging and tumour markers determined treatment outcomes.
Results: Median age was 35 years (range=21-57 years) with 26 males and 2 females. Median time to first relapse was 6 months. Median time to progression after 2nd line chemotherapy was 17.3 months. Fourteen patients had peripheral neurotoxicity (≥Grade 2) (50%), 4 patients developed renal failure, 5 had ototoxicity (≥Grade 2) and 1 patient developed acute myeloid leukaemia. Median survival was 62 months and 16 patients (57%) are in clinical follow-up with surveillance.
Conclusion: In relapsed GCT patients, median survival may exceed 5 years post-HDCT and SCT.


© 2020 The Author(s). The unrestricted non-commercial use, distribution and reproduction in any medium of CGP articles for academic reasons is allowed, provided that the original work is properly cited.

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