University of Hertfordshire

  • U. Kues
  • W.V.J. Richardson
  • A.M. Tymon
  • Euphemia Mutasa-Gottgens
  • B. Gottgens
  • S. Gaubatz
  • A. Gregoriades
  • L.A. Casselton
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Original languageEnglish
Pages (from-to)568-577
Number of pages10
JournalGenes and Development
Publication statusPublished - Apr 1992


The A mating-type factor is one of two gene complexes that allows mating cells of the mushroom Coprinus cinereus to recognize self from nonself and to regulate a pathway of sexual development that leads to meiosis and sporulation. We have identified seven A genes separated into two subcomplexes corresponding to the classical A-alpha and A-beta loci. Four genes, one-alpha and three-beta, all coding for proteins with a homeo domain-related motif, determine A-factor specificity; their allelic forms are so different in sequence that they do not cross-hybridize. It requires only one of these four genes to be heteroallelic in a cell to trigger A-regulated sexual development, and it is the different combinations of their alleles that generate the multiple A factors found in nature. The other three genes cause no change in cell morphology and may regulate the activity of the four specificity genes

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