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The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation. / Howard, Lorelei; Javadi, Amir; Yu, Yichao; Mill, Ravi; Morrison, Laura; Knight, Rebecca; Loftus, Michelle; Staskute, Laura; Spiers, Hugo.

In: Current Biology, Vol. 24, No. 12, 16.06.2014, p. 1331-1340.

Research output: Contribution to journalArticlepeer-review

Harvard

Howard, L, Javadi, A, Yu, Y, Mill, R, Morrison, L, Knight, R, Loftus, M, Staskute, L & Spiers, H 2014, 'The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation', Current Biology, vol. 24, no. 12, pp. 1331-1340. https://doi.org/10.1016/j.cub.2014.05.001

APA

Howard, L., Javadi, A., Yu, Y., Mill, R., Morrison, L., Knight, R., Loftus, M., Staskute, L., & Spiers, H. (2014). The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation. Current Biology, 24(12), 1331-1340. https://doi.org/10.1016/j.cub.2014.05.001

Vancouver

Author

Howard, Lorelei ; Javadi, Amir ; Yu, Yichao ; Mill, Ravi ; Morrison, Laura ; Knight, Rebecca ; Loftus, Michelle ; Staskute, Laura ; Spiers, Hugo. / The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation. In: Current Biology. 2014 ; Vol. 24, No. 12. pp. 1331-1340.

Bibtex

@article{b164f2f03e2142028c0b38bf572570af,
title = "The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation",
abstract = "Background: Despite decades of research on spatial memory, we know surprisingly little about how the brain guides navigation to goals. While some models argue vectors are represented for navigational guidance, other models postulate that the path to the goal is computed. Although the hippocampal formation has been implicated in processing spatial goal information it remains unclear whether this region processes path- or vector-related guidance information.Results: Here we report neuroimaging data collected from subjects navigating London{\textquoteright}s Soho district (UK), which reveals that both the path and Euclidean distance to the goal are encoded by the hippocampus during navigation. While activity in the posterior hippocampus was sensitive to the distance along the path, activity in the anterior hippocampus and entorhinal cortex was correlated with the Euclidean distance component of a vector to the goal. During travel periods posterior hippocampal activity was greater the longer the path to the goal, but at decision points activity in this region increased the closer and more direct the path was to the goal. Importantly, sensitivity to the distance was abolished in these brain areas when subjects followed cued instructions on the direction to proceed at junctions.Conclusions: The results indicate that the hippocampus contains representations of both the Euclidean and path distance to goals during navigation. These findings argue for a flexible guidance system housed in the hippocampus that changes how it represents distance to the goal depending on the fluctuating demands of navigation.",
author = "Lorelei Howard and Amir Javadi and Yichao Yu and Ravi Mill and Laura Morrison and Rebecca Knight and Michelle Loftus and Laura Staskute and Hugo Spiers",
note = "Open Access funded by the Wellcome Trust - grant 094850/Z/10/Z. This is an open access article under the CC BY Attribution3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) . You are free to copy and redistribute the material in any medium or format, remix, transform, and build upon the material for any purpose, even commercially, under the following terms: You must give appropriate credit, provide a link to the license, and indicate if changes were made. The version of record, Lorelei R. Howard, et. a., 'The Hippocampus and Entorhinal Cortex Encode the Path and Euclidean Distances to Goals during Navigation', Current Biology, Vol. 24(12): 1331-1340, first published online 5 June 2014, is available via doi: http://dx.doi.org/10.1016/j.cub.2014.05.001 Published by Elsevier. ",
year = "2014",
month = jun,
day = "16",
doi = "10.1016/j.cub.2014.05.001",
language = "English",
volume = "24",
pages = "1331--1340",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "12",

}

RIS

TY - JOUR

T1 - The hippocampus and entorhinal cortex encode the path and euclidean distances to goals during navigation

AU - Howard, Lorelei

AU - Javadi, Amir

AU - Yu, Yichao

AU - Mill, Ravi

AU - Morrison, Laura

AU - Knight, Rebecca

AU - Loftus, Michelle

AU - Staskute, Laura

AU - Spiers, Hugo

N1 - Open Access funded by the Wellcome Trust - grant 094850/Z/10/Z. This is an open access article under the CC BY Attribution3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) . You are free to copy and redistribute the material in any medium or format, remix, transform, and build upon the material for any purpose, even commercially, under the following terms: You must give appropriate credit, provide a link to the license, and indicate if changes were made. The version of record, Lorelei R. Howard, et. a., 'The Hippocampus and Entorhinal Cortex Encode the Path and Euclidean Distances to Goals during Navigation', Current Biology, Vol. 24(12): 1331-1340, first published online 5 June 2014, is available via doi: http://dx.doi.org/10.1016/j.cub.2014.05.001 Published by Elsevier.

PY - 2014/6/16

Y1 - 2014/6/16

N2 - Background: Despite decades of research on spatial memory, we know surprisingly little about how the brain guides navigation to goals. While some models argue vectors are represented for navigational guidance, other models postulate that the path to the goal is computed. Although the hippocampal formation has been implicated in processing spatial goal information it remains unclear whether this region processes path- or vector-related guidance information.Results: Here we report neuroimaging data collected from subjects navigating London’s Soho district (UK), which reveals that both the path and Euclidean distance to the goal are encoded by the hippocampus during navigation. While activity in the posterior hippocampus was sensitive to the distance along the path, activity in the anterior hippocampus and entorhinal cortex was correlated with the Euclidean distance component of a vector to the goal. During travel periods posterior hippocampal activity was greater the longer the path to the goal, but at decision points activity in this region increased the closer and more direct the path was to the goal. Importantly, sensitivity to the distance was abolished in these brain areas when subjects followed cued instructions on the direction to proceed at junctions.Conclusions: The results indicate that the hippocampus contains representations of both the Euclidean and path distance to goals during navigation. These findings argue for a flexible guidance system housed in the hippocampus that changes how it represents distance to the goal depending on the fluctuating demands of navigation.

AB - Background: Despite decades of research on spatial memory, we know surprisingly little about how the brain guides navigation to goals. While some models argue vectors are represented for navigational guidance, other models postulate that the path to the goal is computed. Although the hippocampal formation has been implicated in processing spatial goal information it remains unclear whether this region processes path- or vector-related guidance information.Results: Here we report neuroimaging data collected from subjects navigating London’s Soho district (UK), which reveals that both the path and Euclidean distance to the goal are encoded by the hippocampus during navigation. While activity in the posterior hippocampus was sensitive to the distance along the path, activity in the anterior hippocampus and entorhinal cortex was correlated with the Euclidean distance component of a vector to the goal. During travel periods posterior hippocampal activity was greater the longer the path to the goal, but at decision points activity in this region increased the closer and more direct the path was to the goal. Importantly, sensitivity to the distance was abolished in these brain areas when subjects followed cued instructions on the direction to proceed at junctions.Conclusions: The results indicate that the hippocampus contains representations of both the Euclidean and path distance to goals during navigation. These findings argue for a flexible guidance system housed in the hippocampus that changes how it represents distance to the goal depending on the fluctuating demands of navigation.

U2 - 10.1016/j.cub.2014.05.001

DO - 10.1016/j.cub.2014.05.001

M3 - Article

VL - 24

SP - 1331

EP - 1340

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 12

ER -