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  • Clare B O'Donovan
  • Marianne C Walsh
  • Hannah Forster
  • Clara Woolhead
  • Carlos Celis-Morales
  • Anna L Macready
  • Cyril F M Marsaux
  • Santiago Navas-Carretero
  • Rodrigo San-Cristobal
  • Silvia Kolossa
  • Christina Mavrogianni
  • Christina P Lambrinou
  • George Moschonis
  • Magdalena Godlewska
  • Agnieszka Surwillo
  • Jildau Bouwman
  • Keith Grimaldi
  • Iwona Traczyk
  • Christian A Drevon
  • Hannelore Daniel
  • Yannis Manios
  • J Alfredo Martinez
  • Wim H M Saris
  • Julie A Lovegrove
  • John C Mathers
  • Michael J Gibney
  • Lorraine Brennan
  • Eileen R Gibney
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Original languageEnglish
Pages (from-to)25
JournalGenes and Nutrition
Volume11
Issue25
DOIs
Publication statusPublished - 29 Sep 2016

Abstract

BACKGROUND: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention.

RESULTS: There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p = 0.010). Baseline folate intakes were 412 ± 172, 391 ± 190 and 410 ± 186 μg per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate.

CONCLUSIONS: These results suggest that knowledge of MTHFR 677C → T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.

TRIAL REGISTRATION: ClinicalTrials.gov NCT01530139.

Notes

© 2016 The Author(s). Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

ID: 10583221