University of Hertfordshire

From the same journal

By the same authors

The increasing indications of FDG-PET/CT in the staging and management of Invasive Bladder Cancer

Research output: Contribution to journalArticlepeer-review

  • Nicolas Pavlos Omorphos
  • Aruni Ghose
  • John Hayes
  • Abhinav Kandala
  • Prokar Dasgupta
  • Anand Sharma
  • Nikhil Vasdev
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Original languageEnglish
JournalUrologic Oncology
Publication statusAccepted/In press - 14 May 2022

Abstract

Context:
The management of locally advanced Muscle Invasive Bladder Cancer (MIBC) often necessitates neo-adjuvant chemotherapy (NAC) to eliminate any micro-metastatic disease prior to definitive radical cystectomy (RC) and pelvic lymph node dissection (PLND). The use of new imaging techniques, such as FDG-PET/CT, enables more accurate initial staging of bladder cancer. In addition, it appears to be better at assessing cancer response to NAC, compared to the more traditional CT and MRI imaging, which is crucial for definitive peri-operative surgical planning.

Objective: Review the evolving indications of functional F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) imaging in MIBC.

Conclusion: FDG-PET/CT is being increasingly utilised in local nodal staging and detection of metastatic disease in MIBC. Furthermore, it appears more accurate than conventional imaging modalities (CT/MRI) in assessing tumour response to NAC. This enables the earlier detection of tumour response and/or residual disease, impacting factors such as the duration of chemotherapy, with its associated adverse effects, and the timing of surgical intervention

ID: 27355585