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The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes. / Najib, Omaima N.; Martin, Gary P.; Kirton, Stewart B.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh.

In: Membranes, Vol. 11, No. 1, 57, 14.01.2021.

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@article{1a3de316e5da4d20899d553a64b7baf2,
title = "The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes",
abstract = "In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component over another into a model barrier membrane (silicone) from blended vehicles (comprising two from the common excipients isohexadecane (IHD), hexadecane (HD), isopropyl myristate (IPM), oleic acid (OA) and liquid paraffin). Second, to study the effect of membrane-vehicle interactions on the diffusion of model permeants (caffeine (CF), methyl paraben (MP) and butyl paraben (BP)) from blended vehicles. Selective sorption and partition of some oils (especially IHD and IPM) at the expense of other oils (such as OA) was demonstrated to take place. For example, the membrane composition of IHD was enriched compared to a donor solution of IHDOA: 41%, 63% and 82% IHD, compared to donor solution composition of 25%, 50% and 75% IHD, respectively. Pre-soaking the membrane in IHD, HD or LP, rather than phosphate buffer, enhanced the flux of MP through the membrane by 2.6, 1.7 and 1.3 times, respectively. The preferential sorption of individual oil components from mixtures altered the barrier properties of silicone membrane, and enhanced the permeation of CF, MP and BP, which are typically co-formulated in topical products.",
keywords = "Binary vehicles, Membrane vehicle interaction, Penetration enhancement, Selective sorption, Silicone membrane",
author = "Najib, {Omaima N.} and Martin, {Gary P.} and Kirton, {Stewart B.} and Botha, {Michelle J.} and Sallam, {Al Sayed} and Darragh Murnane",
note = "{\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)",
year = "2021",
month = jan,
day = "14",
doi = "10.3390/membranes11010057",
language = "English",
volume = "11",
journal = "Membranes",
issn = "2077-0375",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes

AU - Najib, Omaima N.

AU - Martin, Gary P.

AU - Kirton, Stewart B.

AU - Botha, Michelle J.

AU - Sallam, Al Sayed

AU - Murnane, Darragh

N1 - © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)

PY - 2021/1/14

Y1 - 2021/1/14

N2 - In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component over another into a model barrier membrane (silicone) from blended vehicles (comprising two from the common excipients isohexadecane (IHD), hexadecane (HD), isopropyl myristate (IPM), oleic acid (OA) and liquid paraffin). Second, to study the effect of membrane-vehicle interactions on the diffusion of model permeants (caffeine (CF), methyl paraben (MP) and butyl paraben (BP)) from blended vehicles. Selective sorption and partition of some oils (especially IHD and IPM) at the expense of other oils (such as OA) was demonstrated to take place. For example, the membrane composition of IHD was enriched compared to a donor solution of IHDOA: 41%, 63% and 82% IHD, compared to donor solution composition of 25%, 50% and 75% IHD, respectively. Pre-soaking the membrane in IHD, HD or LP, rather than phosphate buffer, enhanced the flux of MP through the membrane by 2.6, 1.7 and 1.3 times, respectively. The preferential sorption of individual oil components from mixtures altered the barrier properties of silicone membrane, and enhanced the permeation of CF, MP and BP, which are typically co-formulated in topical products.

AB - In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component over another into a model barrier membrane (silicone) from blended vehicles (comprising two from the common excipients isohexadecane (IHD), hexadecane (HD), isopropyl myristate (IPM), oleic acid (OA) and liquid paraffin). Second, to study the effect of membrane-vehicle interactions on the diffusion of model permeants (caffeine (CF), methyl paraben (MP) and butyl paraben (BP)) from blended vehicles. Selective sorption and partition of some oils (especially IHD and IPM) at the expense of other oils (such as OA) was demonstrated to take place. For example, the membrane composition of IHD was enriched compared to a donor solution of IHDOA: 41%, 63% and 82% IHD, compared to donor solution composition of 25%, 50% and 75% IHD, respectively. Pre-soaking the membrane in IHD, HD or LP, rather than phosphate buffer, enhanced the flux of MP through the membrane by 2.6, 1.7 and 1.3 times, respectively. The preferential sorption of individual oil components from mixtures altered the barrier properties of silicone membrane, and enhanced the permeation of CF, MP and BP, which are typically co-formulated in topical products.

KW - Binary vehicles

KW - Membrane vehicle interaction

KW - Penetration enhancement

KW - Selective sorption

KW - Silicone membrane

UR - http://www.scopus.com/inward/record.url?scp=85100323853&partnerID=8YFLogxK

U2 - 10.3390/membranes11010057

DO - 10.3390/membranes11010057

M3 - Article

C2 - 33466758

AN - SCOPUS:85100323853

VL - 11

JO - Membranes

JF - Membranes

SN - 2077-0375

IS - 1

M1 - 57

ER -