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Original language | English |
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Article number | 208P |
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Journal | pA2 online |
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Volume | 11 |
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Issue | 3 |
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Publication status | Published - Dec 2013 |
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Event | Pharmacology 2013 [BPS Winter Meeting] - London, United Kingdom Duration: 17 Dec 2013 → 19 Dec 2013 |
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Abstract
Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)
ID: 7545908