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The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus). / Pritchard, Sara; Jackson, Michael; Lione, Lisa; Benham, Christopher; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M.

In: pA2 online, Vol. 11, No. 3, 208P, 12.2013.

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@article{1fea178e2daf4c2195824b551d0ccbc1,
title = "The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)",
abstract = "Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson{\textquoteright}s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug na{\"i}ve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)",
author = "Sara Pritchard and Michael Jackson and Lisa Lione and Christopher Benham and Sarah Rose and Peter Jenner and Iravani, {Mahmoud M.}",
year = "2013",
month = dec,
language = "English",
volume = "11",
journal = "pA2 online",
issn = "1741-1157",
publisher = "British Pharmacological Society",
number = "3",
note = "Pharmacology 2013 [BPS Winter Meeting] ; Conference date: 17-12-2013 Through 19-12-2013",

}

RIS

TY - JOUR

T1 - The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus)

AU - Pritchard, Sara

AU - Jackson, Michael

AU - Lione, Lisa

AU - Benham, Christopher

AU - Rose, Sarah

AU - Jenner, Peter

AU - Iravani, Mahmoud M.

PY - 2013/12

Y1 - 2013/12

N2 - Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)

AB - Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)

M3 - Meeting abstract

VL - 11

JO - pA2 online

JF - pA2 online

SN - 1741-1157

IS - 3

M1 - 208P

T2 - Pharmacology 2013 [BPS Winter Meeting]

Y2 - 17 December 2013 through 19 December 2013

ER -