University of Hertfordshire

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Theranostic NIR-active Conjugated Polymer Nanoparticles

Research output: Contribution to journalArticlepeer-review

Standard

Theranostic NIR-active Conjugated Polymer Nanoparticles. / Zhao, Miao; Leggett, Edward; Bourke, Struan; Poursanidou, Souzana; Carter-Searjeant, Sadie; Po, Steve; Palma do Carmo, Marciano; Dailey, Lea Ann; Manning, Philip; Ryan, Sean; Urbano, Laura; Green, Mark; Rakovich, Aliaksandra.

In: ACS Nano, Vol. 15, No. 5, 12.05.2021, p. 8790-8802.

Research output: Contribution to journalArticlepeer-review

Harvard

Zhao, M, Leggett, E, Bourke, S, Poursanidou, S, Carter-Searjeant, S, Po, S, Palma do Carmo, M, Dailey, LA, Manning, P, Ryan, S, Urbano, L, Green, M & Rakovich, A 2021, 'Theranostic NIR-active Conjugated Polymer Nanoparticles', ACS Nano, vol. 15, no. 5, pp. 8790-8802. https://doi.org/10.1021/acsnano.1c01257

APA

Zhao, M., Leggett, E., Bourke, S., Poursanidou, S., Carter-Searjeant, S., Po, S., Palma do Carmo, M., Dailey, L. A., Manning, P., Ryan, S., Urbano, L., Green, M., & Rakovich, A. (2021). Theranostic NIR-active Conjugated Polymer Nanoparticles. ACS Nano, 15(5), 8790-8802. https://doi.org/10.1021/acsnano.1c01257

Vancouver

Zhao M, Leggett E, Bourke S, Poursanidou S, Carter-Searjeant S, Po S et al. Theranostic NIR-active Conjugated Polymer Nanoparticles. ACS Nano. 2021 May 12;15(5):8790-8802. https://doi.org/10.1021/acsnano.1c01257

Author

Zhao, Miao ; Leggett, Edward ; Bourke, Struan ; Poursanidou, Souzana ; Carter-Searjeant, Sadie ; Po, Steve ; Palma do Carmo, Marciano ; Dailey, Lea Ann ; Manning, Philip ; Ryan, Sean ; Urbano, Laura ; Green, Mark ; Rakovich, Aliaksandra. / Theranostic NIR-active Conjugated Polymer Nanoparticles. In: ACS Nano. 2021 ; Vol. 15, No. 5. pp. 8790-8802.

Bibtex

@article{1ac7d61c8f4c477b8a7e6e31d2df0356,
title = "Theranostic NIR-active Conjugated Polymer Nanoparticles",
abstract = "Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPN particles both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Importantly, we show that the photosensitizing ability of our CPNs was largely determined by the nature of the stabilizing shell: coating the CPNs with a pluronic F127 copolymer led to an improvement of photoinitiated ROS production, while using PSMA instead completely quenched said process. To best of our knowledge, this work is the first to demonstrate the modulation of the photosensitizing capability of CPNs via an appropriate selection of stabilizing material and one that opens a new gateway to the design of theranostic probes based on CPNs. ",
keywords = "conjugated polymer nanoparticles, theranostic probe, NIR-I, reactive oxygen species, photodynamic therapy",
author = "Miao Zhao and Edward Leggett and Struan Bourke and Souzana Poursanidou and Sadie Carter-Searjeant and Steve Po and {Palma do Carmo}, Marciano and Dailey, {Lea Ann} and Philip Manning and Sean Ryan and Laura Urbano and Mark Green and Aliaksandra Rakovich",
note = "{\textcopyright} 2021 American Chemical Society. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1021/acsnano.1c01257",
year = "2021",
month = may,
day = "12",
doi = "10.1021/acsnano.1c01257",
language = "English",
volume = "15",
pages = "8790--8802",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Theranostic NIR-active Conjugated Polymer Nanoparticles

AU - Zhao, Miao

AU - Leggett, Edward

AU - Bourke, Struan

AU - Poursanidou, Souzana

AU - Carter-Searjeant, Sadie

AU - Po, Steve

AU - Palma do Carmo, Marciano

AU - Dailey, Lea Ann

AU - Manning, Philip

AU - Ryan, Sean

AU - Urbano, Laura

AU - Green, Mark

AU - Rakovich, Aliaksandra

N1 - © 2021 American Chemical Society. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1021/acsnano.1c01257

PY - 2021/5/12

Y1 - 2021/5/12

N2 - Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPN particles both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Importantly, we show that the photosensitizing ability of our CPNs was largely determined by the nature of the stabilizing shell: coating the CPNs with a pluronic F127 copolymer led to an improvement of photoinitiated ROS production, while using PSMA instead completely quenched said process. To best of our knowledge, this work is the first to demonstrate the modulation of the photosensitizing capability of CPNs via an appropriate selection of stabilizing material and one that opens a new gateway to the design of theranostic probes based on CPNs.

AB - Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been evaluated. The main absorption and emission bands of the prepared CPN particles both fell within the NIR-I (650-950 nm) transparency window, allowing facile and efficient implementation of our CPNs as bioimaging agents, as demonstrated in this work for A549 human lung cancer cell cultures. The prepared CPN samples were also shown to produce reactive oxygen species (ROS) upon photoexcitation in the near infrared or ultraviolet spectral regions, both in aqueous solutions and in HaCaT keratinocyte cell cultures. Importantly, we show that the photosensitizing ability of our CPNs was largely determined by the nature of the stabilizing shell: coating the CPNs with a pluronic F127 copolymer led to an improvement of photoinitiated ROS production, while using PSMA instead completely quenched said process. To best of our knowledge, this work is the first to demonstrate the modulation of the photosensitizing capability of CPNs via an appropriate selection of stabilizing material and one that opens a new gateway to the design of theranostic probes based on CPNs.

KW - conjugated polymer nanoparticles

KW - theranostic probe

KW - NIR-I

KW - reactive oxygen species

KW - photodynamic therapy

U2 - 10.1021/acsnano.1c01257

DO - 10.1021/acsnano.1c01257

M3 - Article

VL - 15

SP - 8790

EP - 8802

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 5

ER -